(2R,4S)-Sacubitril with CAS No:761373-05-1 is an impurity standard of Sacubitril.
Chemically, sacubitril is the prodrug form of sacubitrilat, the active neprilysin inhibitor. The chemical name for sacubitrilat is (2S,4S)-2-ethoxy-4-{[(3S)-3-methyl-4-(methylamino)-4-oxopentanoyl]amino}-5-propan-2-yl-5H-imidazo[4,5-d]pyridazin-1-one. Sacubitril/valsartan is a combination medication used in the treatment of heart failure with reduced ejection fraction (HFrEF). Sacubitril inhibits neprilysin, an enzyme that breaks down natriuretic peptides involved in cardiovascular homeostasis. This inhibition leads to increased levels of natriuretic peptides, promoting vasodilation and natriuresis. Valsartan, an angiotensin receptor blocker, complements this action by blocking the vasoconstrictor effects of the renin-angiotensin-aldosterone system. The combined effect of sacubitril/valsartan helps improve cardiac function, reduce symptoms, and enhance outcomes in patients with HFrEF.
Buy high quality (2R,4S)-Sacubitril from from Chemicea Pharmaceuticals. Chemicea Pharmaceuticals is one of the leading manufacturer and exporter of (2R,4S)-Sacubitril

(2R,4S)-Sacubitril

CAT. No. CP-S18023
CAS. No. 761373-05-1
Mol. F. C24H29NO5
Mol. Wt. 411.50
Stock Status In Stock
Rel. Cas No 149690-06-2 (Sodium salt)
Sample PDF VIEW COA Sample PDF VIEW MSDS
  • Category: Impurity Standards
  • Synonyms: Sacubitril Enantiomer
  • Chemical Name: (2S,4R)-4-[(3-Carboxy-1-oxopropyl)amino]-4-[(p-phenylphenyl)methyl]-2-methylbutanoic acid ethyl ester

(2R,4S)-Sacubitril, also known as Sacubitril Enantiomer, is a structurally characterized enantiomeric impurity of Sacubitril, chemically identified as (2S,4R)-4-[(3-Carboxy-1-oxopropyl)amino]-4-[(p-phenylphenyl)methyl]-2-methylbutanoic acid ethyl ester. Chemicea supplies this impurity reference standard with comprehensive analytical characterization data to support pharmaceutical quality, regulatory, and research requirements.

FAQ

(2R,4S)-Sacubitril is a known related compound associated with the synthesis, degradation, or manufacturing process of (2R,4S)-Sacubitril. It is commonly used as a reference standard for impurity profiling and analytical studies.

(2R,4S)-Sacubitril helps pharmaceutical companies identify, quantify, and monitor impurities, ensuring product quality and regulatory compliance.

(2R,4S)-Sacubitril can be analyzed using HPLC, UPLC, LC-MS, GC-MS (where applicable), and other advanced chromatographic and spectroscopic techniques.

Yes, (2R,4S)-Sacubitril is widely used as a reference standard for qualitative and quantitative analysis of impurities in pharmaceutical products.

It assists in establishing specificity, accuracy, precision, linearity, detection limits, and quantification limits during analytical method validation studies.

(2R,4S)-Sacubitril can be sourced from Chemicea, a trusted supplier of pharmaceutical impurities, reference standards, metabolites, and analytical research materials for the pharmaceutical industry.

(2R,4S)-Sacubitril may form during the synthesis, purification, storage, or degradation of the parent drug substance under specific process or environmental conditions.

Chemicea provides COA, H-NMR, MASS, HPLC, and TGA reports as standard with (2R,4S)-Sacubitril. Additional reports such as CNMR, IR, UV, DEPT, Water Content, and CHNS can be provided upon request, subject to availability.

The CAS number for (2R,4S)-Sacubitril is 761373-05-1.

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