Services

SYNTHETIC CHEMISTRY SERVICES

At Chemicea, we offer a wide range of synthetic chemistry services tailored to support from drug discovery to commercialization. Our synthesis capabilities are backed by state-of-the-art infrastructure and an experienced chemistry team.

Small Molecule Synthesis

Chemicea specializes in the custom synthesis of small organic compounds including heterocycles, chiral centers, bioactive scaffolds, and complex building blocks. We offer milligram to multigram scale synthesis with an emphasis on structural integrity, high purity, and reproducibility. Our experienced team employs modern synthetic methods, including asymmetric synthesis and catalytic transformations, ensuring quick turnaround.

Large Molecule Synthesis

We offer expertise in synthesizing complex high-molecular-weight compounds such as peptides, macrocycles, and multifunctional drug-like structures. Our capabilities include solid-phase and solution-phase peptide synthesis, macrocyclization, and conjugate preparation. These services support advanced research, lead optimization, and biological evaluation with scalable protocols and analytical validation.

Contract Research & Manufacturing Services (CRAMS)

Chemicea provides fully integrated CRAMS solutions covering route scouting, process optimization, and scalable synthesis from mg to kilogram quantities. We support client programs under strict confidentiality, IP security, and global quality standards. Whether through PO-based assignments or long-term FTE collaborations, we ensure reliable R&D and manufacturing outcomes tailored to specific project needs. Every project is executed under comprehensive QA oversight, supported by COA, MSDS, NMR, MS, HPLC.

Core Synthetic Capabilities
Heterocyclic Chemistry: Synthesis of O-, N-, S-, and P-containing heterocycles Development of fused-ring systems including azaindoles, thiophenes, thiazoles, and benzofurans	High-Temperature Reactions: Thermally driven reactions up to 290°C Designed for robust and scalable synthesis under controlled conditions
Transition Metal-Catalyzed Reactions: Suzuki, Heck, Negishi, Buchwald–Hartwig couplings C–P, C–S, C–B, C–Sn, and C–Si bond formations C–H activation and direct functionalization strategies	Nitration, Reduction & Rearrangement: Selective nitration and chemoselective reductions Functional group migrations and complex rearrangements
Sensitive & Pyrophoric Reagents: Handling of highly reactive reagents: Li, Mg, Zn, metal cyanides, carbonyls Advanced applications in Grignard and catalytic hydrogenation chemistry	Specialty Synthesis Techniques: Cryogenic reactions and low-temperature transformations Fluorination, deuteration, stable isotope labeling Cyclopropanation and complex molecule construction
Gaseous Reagent Handling: Reactions involving H₂, Cl₂, O₂, CO, CO₂, SO₃ Expertise in ozonolysis, selective halogenation, and gas-phase synthesis

PO-Based Projects

We offer quick-turnaround synthesis solutions under a Purchase Order (PO) model, tailored for early-stage discovery, medicinal chemistry intermediates, building blocks, impurities and reference standard development. We can offer from mg to kg scale, ensuring rapid delivery without long-term commitment. Ideal for clients seeking flexible, project-specific support with full analytical documentation.

FTE-Based Projects

We provide dedicated Full-Time Equivalent (2 to 50 FTE) scientists to support long-term collaborations for your discovery, medicinal chemistry and scale up. This model ensures weekly or biweekly updates includes presentations, video conference meetings. We have dedicated team of PhD’s, Experienced Master’s scientist for FTE projects

API Intermediate Synthesis

Impurity Synthesis : Chemicea is a leading provider of pharmaceutical impurity standards, supporting global R&D, quality control, and regulatory compliance for pharmaceutical development.

Our Capabilities :

• Custom synthesis of process-related, degradation, genotoxic, and metabolite impurities
• Specialized nitrosamine synthesis including:
  • NDSRIs (API nitroso)
  • Nitrosamine metabolites
  • Stable isotope-labeled nitrosamines
  • Glucuronide-linked variants
• Supplied with comprehensive analytical data: COA, NMR, MS, HPLC
• Fully compliant with USP, EP, BP, and ICH regulatory guidelines