Nitrosamines can be formed through various chemical processes, including the reaction between nitrites and secondary amines in certain conditions. It is a N-Nitroso of secondary amine present in Ethambutol. Nitrosamines are part of a broader class of compounds known as N-nitroso compounds.
Ethambutol, a key antimycobacterial agent, is primarily employed in the treatment of tuberculosis. Its chemical structure involves an ethylenediamine derivative. Ethambutol inhibits the synthesis of mycobacterial cell wall components by targeting arabinosyl transferases. This disruption impairs cell wall formation, hindering bacterial growth. Administered orally, ethambutol is a crucial component in multidrug regimens for tuberculosis, contributing to the effective management of the disease while minimizing resistance development.
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