Abiraterone acetate is a prodrug of abiraterone, an androgen biosynthesis inhibitor. Structurally, it is an acetate ester derivative of abiraterone. Chemically, abiraterone acetate is (3β)-17-(3-pyridinyl)androsta-5,16-dien-3-yl acetate. Upon oral administration, abiraterone acetate is rapidly hydrolyzed to abiraterone, the active form of the drug.Abiraterone acetate is indicated for the treatment of metastatic castration-resistant prostate cancer (mCRPC), a form of prostate cancer that has spread to other parts of the body and no longer responds to hormone therapy. Abiraterone works by inhibiting the enzyme cytochrome P450 17α-hydroxylase/C17,20-lyase (CYP17), which is involved in the synthesis of androgens (male hormones) such as testosterone.
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