Abrocitinib is a small molecule JAK inhibitor designed to selectively target and inhibit Janus kinase 1 (JAK1). Structurally, it is a pyrazolecarboxamide compound. Chemically, abrocitinib is (S)-3-(cyclopentylmethoxy)-4-(4-(methylsulfonyl)phenyl)-N-(quinolin-3-ylmethyl)pyrazole-1-carboxamide. This unique chemical structure allows abrocitinib to specifically bind to and inhibit the activity of JAK1, a key enzyme involved in signaling pathways associated with inflammation and immune response.Abrocitinib is indicated for the treatment of moderate to severe atopic dermatitis (eczema) in adults who are candidates for systemic therapy. It works by blocking the activity of JAK1, which plays a critical role in the signaling pathways involved in the pathogenesis of atopic dermatitis.
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