Alectinib is a medication used in the treatment of non-small cell lung cancer (NSCLC).Alectinib is a small molecule tyrosine kinase inhibitor (TKI) that selectively targets and inhibits the activity of anaplastic lymphoma kinase (ALK) and receptor tyrosine kinase ROS1. Structurally, it is a pyrimidine-based compound. Chemically, alectinib is (R)-1-(2,6-dichloro-3-fluoro-phenyl)-2-(1H-indazol-5-yl)ethanol. This unique chemical structure allows alectinib to selectively bind to and inhibit the activity of ALK and ROS1, which are mutated or overexpressed in certain types of NSCLC.Alectinib is indicated for the treatment of patients with metastatic NSCLC whose tumors are ALK-positive as detected by an FDA-approved test. It is also indicated for the treatment of metastatic NSCLC whose tumors are ROS1-positive.
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