Alfacalcidol is a synthetic vitamin D analog, chemically known as 1-alpha-hydroxycholecalciferol. It is used therapeutically to treat various disorders related to calcium and bone metabolism, particularly in conditions of vitamin D deficiency or impaired renal function. Alfacalcidol is biologically active and requires less metabolic activation compared to native vitamin D, making it advantageous in patients with liver or kidney dysfunction. It acts by promoting intestinal calcium absorption, enhancing bone mineralization, and regulating parathyroid hormone (PTH) secretion.
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