Alitretinoin, also known as 9-cis-retinoic acid, is a synthetic retinoid derived from vitamin A. It is primarily used topically in the treatment of severe chronic hand eczema (CHE) unresponsive to conventional therapy. Chemically, alitretinoin is a structural analog of all-trans retinoic acid, with a specific isomerization to the 9-cis form to enhance its efficacy.Alitretinoin works by modulating cell proliferation, differentiation, and inflammation, thereby improving the symptoms of hand eczema. Its precise mechanism of action in this condition is not fully understood but is thought to involve the regulation of cytokines and growth factors involved in skin inflammation and repair. Clinical studies have shown alitretinoin to be effective in reducing the severity of hand eczema and improving quality of life in patients with severe CHE.
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