Altiratinib is an investigational small molecule inhibitor targeting several receptor tyrosine kinases (RTKs), including MET, TIE-2, and VEGFR2. Chemically, it belongs to the class of multi-kinase inhibitors. Altiratinib exerts its anti-cancer effects by inhibiting the signaling pathways involved in tumor growth, angiogenesis, and metastasis. It has shown promising preclinical activity in various solid tumors, including non-small cell lung cancer (NSCLC), renal cell carcinoma (RCC), and hepatocellular carcinoma (HCC). Clinical trials are underway to evaluate the safety and efficacy of altiratinib either as monotherapy or in combination with other anti-cancer agents for the treatment of advanced or metastatic cancers. Altiratinibs ability to target multiple pathways implicated in cancer progression makes it a potential therapeutic option for patients with resistant or refractory tumors. However, further research is needed to determine its precise mechanisms of action and therapeutic potential in clinical settings.
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