Altizide is a medication that combines two active ingredients: hydrochlorothiazide and the potassium-sparing diuretic spironolactone. Hydrochlorothiazide is a thiazide diuretic that works by inhibiting sodium reabsorption in the distal convoluted tubule of the kidneys, leading to increased excretion of sodium and water, thereby reducing blood volume and lowering blood pressure. Spironolactone, on the other hand, is a potassium-sparing diuretic that antagonizes aldosterone receptors, leading to increased sodium excretion and potassium retention. This combination helps to maintain potassium levels while effectively reducing blood pressure.
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