Altretamine, also known by its brand name Hexalen, is an alkylating agent used in the treatment of certain types of cancer, particularly ovarian cancer. Chemically, it is a synthetic derivative of triethylene melamine. Altretamine works by interfering with DNA synthesis and function, leading to the inhibition of cancer cell growth and proliferation. It is commonly used as a second-line or salvage therapy for patients with recurrent ovarian cancer who have not responded to other treatments. Altretamine may be used alone or in combination with other chemotherapy agents. Common side effects associated with altretamine treatment include myelosuppression (decreased blood cell production), gastrointestinal symptoms, and neurotoxicity.
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