Amiloride is a potassium-sparing diuretic commonly used in the treatment of conditions such as hypertension and heart failure. It belongs to a class of medications known as potassium-sparing diuretics, and its primary mechanism of action involves inhibiting the epithelial sodium channels in the distal tubules of the kidneys. By blocking these channels, amiloride reduces sodium reabsorption, leading to increased excretion of sodium and water while retaining potassium. This diuretic effect helps lower blood pressure and reduce fluid retention in conditions where excess fluid accumulation is a concern. Amiloride is often used in combination with other diuretics or antihypertensive medications for a synergistic therapeutic effect. Additionally, it may be prescribed to counteract potassium loss caused by other diuretics.
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