Amphotericin B, a polyene macrolide antibiotic derived from Streptomyces nodosus, possesses a unique chemical structure comprising a hydrophilic polyhydroxylated chain and a lipophilic region with conjugated double bonds and a carboxyl group. This molecular arrangement enables amphotericin B to interact with ergosterol in fungal cell membranes, disrupting membrane integrity. Widely recognized for its broad spectrum of antifungal activity, amphotericin B is a crucial treatment option for severe and life-threatening fungal infections, including those caused by Candida, Aspergillus, Cryptococcus, and certain strains of Mucorales.
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