Amrubicin is a synthetic anthracycline antineoplastic agent used in the treatment of various cancers, particularly lung cancer and other solid tumors. Its chemical structure includes a tetracyclic anthracycline ring system. Amrubicin works by inhibiting the replication of cancer cells through intercalation into DNA and inhibition of topoisomerase II, an enzyme involved in DNA replication.Amrubicin is often used as a second- or third-line treatment in patients who have not responded to other chemotherapy regimens. It has shown efficacy in treating small cell lung cancer, non-small cell lung cancer, and other malignancies, both as a single agent and in combination with other chemotherapy drugs.
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