Andrographolide is a bioactive compound derived from the leaves and stems of the Andrographis paniculata plant, commonly known as the King of Bitters or Kalmegh. It possesses diverse pharmacological properties, including anti-inflammatory, antioxidant, antimicrobial, and immunomodulatory effects. Chemically, andrographolide is a diterpenoid lactone, characterized by a bicyclic lactone ring structure. It exerts its therapeutic effects by modulating various signaling pathways involved in inflammation and immune responses, such as inhibiting NF-κB activation and reducing the production of pro-inflammatory cytokines.
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