Apatinib is a small molecule tyrosine kinase inhibitor (TKI) that selectively targets vascular endothelial growth factor receptor 2 (VEGFR-2). By inhibiting VEGFR-2, apatinib disrupts angiogenesis, the process by which new blood vessels are formed, thereby inhibiting tumor growth and metastasis. Apatinib is approved for the treatment of advanced or metastatic gastric cancer in patients who have failed prior chemotherapy. It is also being investigated for its potential efficacy in other solid tumors, including colorectal cancer, hepatocellular carcinoma, and non-small cell lung cancer.
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