Astemizole is a member of the piperidine class of antihistamines. Structurally, it is a substituted benzimidazole derivative with a piperidine ring. Chemically, it is (RS)-1-[4-{4-[(4-chlorophenyl)-phenylmethyl]-1-piperidinyl}-1-(4-fluorophenyl)-1-butanol. This compound contains both lipophilic and hydrophilic regions, allowing it to cross the blood-brain barrier and exert its effects centrally.Astemizole was primarily used for the treatment of allergic conditions, including allergic rhinitis (hay fever), urticaria (hives), and allergic conjunctivitis.
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