Atogepant is a small molecule drug belonging to the class of calcitonin gene-related peptide (CGRP) receptor antagonists. Structurally, it is a cycloalkylamine derivative. Chemically, atogepant is (R)-3-((2S,3S)-2-((2,3-difluoro-4-(6-methylpyridin-3-yl)phenyl)thiazolidin-3-yl)-1-(2,2,2-trifluoroethyl)pyrrolidin-3-yl)propanoic acid. The chemical structure of atogepant enables it to selectively and competitively block the CGRP receptors, thereby inhibiting the action of CGRP, a neuropeptide involved in migraine pathophysiology.Atogepant is used for the preventive treatment of migraine in adults. It belongs to a new class of medications known as CGRP receptor antagonists, which have emerged as a promising therapeutic approach for migraine prevention.
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