Avatrombopag is a synthetic small molecule thrombopoietin receptor agonist. Structurally, it is a tricyclic indole-based compound. Avatrombopag is designed to mimic the activity of endogenous thrombopoietin, a hormone that stimulates the production and maturation of platelets from megakaryocytes in the bone marrow. Chemically, avatrombopag is 1-(3-(4-((4-(1-piperidinyl)cyclohexyl)oxy)phenyl)-4,5-dihydro-5-(trifluoromethyl)-1H-pyrazol-1-yl)ethanone.Avatrombopag is approved for the treatment of thrombocytopenia in adult patients with chronic liver disease who are scheduled to undergo a medical or dental procedure.Avatrombopag is administered orally and is typically initiated 10 to 13 days prior to the scheduled procedure and continued through the procedure.
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