Avibactam is a synthetic beta-lactamase inhibitor. Structurally, it belongs to the class of diazabicyclooctanes and contains a bicyclic core with a β-lactam ring. Chemically, it is (Z)-7-[(2R,5S)-2-carbamoyl-7-oxo-1,6-diazabicyclo[3.2.1]octan-6-yl]-3-[(1R)-1-hydroxyethyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid. Avibactam is specifically designed to inhibit a broad spectrum of beta-lactamases, enzymes produced by bacteria that confer resistance to beta-lactam antibiotics such as penicillins, cephalosporins, and carbapenems.Avibactam is used in combination with other antibiotics to enhance their activity against multidrug-resistant bacteria.
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