Cilastatin is an inhibitor of the enzyme dehydropeptidase, commonly co-administered with the antibiotic imipenem to form the combination drug imipenem/cilastatin. This combination is used to treat severe bacterial infections, including intra-abdominal, respiratory tract, and urinary tract infections, particularly those caused by multidrug-resistant bacteria. Cilastatins role is to prevent the rapid breakdown of imipenem in the kidneys, enhancing its effectiveness and duration in the body. The chemistry of cilastatin involves its action as a dehydropeptidase inhibitor, contributing to the therapeutic synergy with imipenem in combating challenging bacterial infections. Buy high quality Cilastatin from Chemicea Pharmaceuticals. Chemicea Pharmaceuticals is one of the leading manufacturer and exporter of Cilastatin