Donepezil N-Oxide, chemically defined as (RS)-2-[(1-Benzyl-1-oxidopiperidin-1-ium-4-yl)methyl]-5,6-dimethoxy-2,3-dihydro-1H-inden-1-one, is the piperidine N-oxide metabolite and oxidative degradation product of Donepezil, with molecular formula C₂₄H₂₉NO₄ and molecular weight 395.50 g/mol. This dipolar N-oxide forms by oxidation of the tertiary benzylpiperidine nitrogen of the parent acetylcholinesterase inhibitor; it is reported as a hepatic metabolite of Donepezil and is also generated under peroxide-mediated oxidative stress, making it relevant to both metabolism and stability-related impurity studies. Manufactured at Chemicea under precisely controlled oxidation and purification protocols, this reference standard supports oxidative degradation profiling, forced-degradation studies, stability-indicating HPLC and LC-MS method development, and metabolite identification for Donepezil Hydrochloride drug substance and finished formulations, in line with ICH Q3A/Q3B impurity requirements. Each batch is supplied with a comprehensive Certificate of Analysis supported by HPLC, ¹H-NMR, and Mass Spectrometry characterization data, ensuring dependable analytical traceability for regulatory submissions and bioanalytical research. CAS No. 120013-84-5 | Explore complete technical documentation, Safety Data Sheet (SDS), and pricing.