Fosfomycin Tromethamine (Fosfomycin Trometamol), chemically defined as [(2R,3S)-3-methyloxiran-2-yl]phosphonic acid compound with 2-amino-2-(hydroxymethyl)propane-1,3-diol (1:1), is the tromethamine salt of the epoxide-containing phosphonic acid antibiotic Fosfomycin, with molecular formula C₃H₇O₄P·C₄H₁₁NO₃ (C₇H₁₈NO₇P) and molecular weight 259.19 g/mol. This salt form improves the aqueous solubility and oral bioavailability of the parent phosphonate, which exerts bactericidal action by irreversibly (covalently) inhibiting MurA (UDP-N-acetylglucosamine enolpyruvyl transferase), the enzyme catalysing the first committed step of bacterial peptidoglycan biosynthesis. Owing to this unique mechanism and its high urinary concentrations, Fosfomycin Tromethamine is active against common Gram-negative and Gram-positive uropathogens, including Escherichia coli and Enterococcus faecalis, and is recommended in many guidelines as a single-dose therapy for uncomplicated cystitis. Supplied by Chemicea as a well-characterized, high-purity reference standard, it supports analytical method development, assay and related-substance testing, stability studies, and quality-control testing across Fosfomycin Tromethamine drug substance and granule/sachet formulation development. Each batch is supplied with a detailed Certificate of Analysis supported by HPLC, ¹H-NMR, and specific optical rotation data in line with EP/USP monograph specifications, ensuring reliable purity and traceability. CAS No. 78964-85-9 (free acid CAS No. 23155-02-4) | Explore complete technical documentation, Safety Data Sheet (SDS), and pricing.