Ibuprofen EP Impurity A, chemically defined as (2RS)-2-[3-(2-Methylpropyl)phenyl]propanoic acid and also known as meta-Ibuprofen, is the meta-substituted positional isomer of Ibuprofen, with molecular formula C₁₃H₁₈O₂ and molecular weight 206.28 g/mol. Structurally, the propanoic acid and isobutyl groups are positioned meta (1,3) on the phenyl ring instead of the para (1,4) arrangement of the active API. It typically originates from the minor meta-acylation product formed during Friedel–Crafts acylation of isobutylbenzene, or from isomeric impurities in the starting material, which are then carried through the subsequent steps. Because it is isobaric with Ibuprofen, it must be resolved chromatographically, making it a key regiochemical marker for method specificity and synthetic-route control. Given its close structural resemblance to the parent NSAID, this compound plays an essential role in impurity profiling, method validation (AMV), and quality-control testing in accordance with EP and BP monograph requirements for Ibuprofen. Manufactured at Chemicea under tightly controlled synthetic and analytical protocols, this reference standard is supplied with a comprehensive Certificate of Analysis supported by HPLC, ¹H-NMR, and Mass Spectrometry data, ensuring reliable analytical traceability for regulatory submissions and pharmaceutical R&D applications. CAS No. 66622-47-7 | Explore complete technical documentation, Safety Data Sheet (SDS), and pricing.