Nitrosamines can be formed through various chemical processes, including the reaction between nitrites and secondary amines in certain conditions. It is a N-Nitroso of secondary amine present in Afatinib. Nitrosamines are part of a broader class of compounds known as N-nitroso compounds.
Afatinib, a second-generation tyrosine kinase inhibitor, is employed in the treatment of non-small cell lung cancer (NSCLC). As an irreversible inhibitor of the epidermal growth factor receptor (EGFR) family, it hinders cancer cell growth by blocking critical signaling pathways. Specifically prescribed for patients with certain EGFR mutations, afatinib has shown efficacy in enhancing progression-free survival.
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