Nitrosamines can be formed through various chemical processes, including the reaction between nitrites and secondary amines in certain conditions. It is a N-Nitroso of secondary amine present in Apremilast. Nitrosamines are part of a broader class of compounds known as N-nitroso compounds.
Apremilast is a medication used in the treatment of certain inflammatory conditions, particularly psoriatic arthritis and moderate to severe plaque psoriasis. It belongs to the class of drugs known as phosphodiesterase-4 (PDE4) inhibitors. Apremilast modulates cellular signaling by inhibiting PDE4, resulting in decreased production of inflammatory mediators such as tumor necrosis factor-alpha (TNF-α). By dampening the inflammatory response, apremilast helps alleviate symptoms associated with psoriatic arthritis and psoriasis. It is administered orally and is often used as a systemic therapy when other treatments have not provided sufficient relief. Apremilast is part of the broader therapeutic landscape for immune-mediated inflammatory disorders, providing an oral and targeted approach to manage symptoms and improve the quality of life for affected individuals.
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