Nitrosamines can be formed through various chemical processes, including the reaction between nitrites and secondary amines in certain conditions. It is a N-Nitroso of secondary amine present in Baricitinib. Nitrosamines are part of a broader class of compounds known as N-nitroso compounds.
Chemically, it is a Janus kinase (JAK) inhibitor. Baricitinib works by targeting and inhibiting specific enzymes involved in the inflammatory process, particularly JAK1 and JAK2. By modulating these pathways, it helps reduce inflammation and slow the progression of rheumatoid arthritis. Baricitinib is typically prescribed in combination with other disease-modifying antirheumatic drugs (DMARDs). Additionally, baricitinib has been investigated for its potential use in certain inflammatory conditions associated with COVID-19.
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