Nitrosamines can be formed through various chemical processes, including the reaction between nitrites and secondary amines in certain conditions. It is a N-Nitroso of secondary amine present in Berotralstat. Nitrosamines are part of a broader class of compounds known as N-nitroso compounds. Berotralstat, with the chemical formula C₃₄H₄₈N₆O₄, is a plasma kallikrein inhibitor utilized for the prophylactic treatment of hereditary angioedema (HAE). HAE, a genetic disorder characterized by recurrent swelling episodes, is effectively managed by berotralstats complex molecular structure. Acting on the enzyme plasma kallikrein, berotralstat disrupts the bradykinin pathway, reducing the formation of bradykinin, a key mediator in angioedema. This targeted mechanism helps prevent and minimize the frequency and severity of HAE attacks. Regular monitoring and adherence to healthcare provider instructions are essential to optimize berotralstats efficacy in the prophylactic management of hereditary angioedema.
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