Nitrosamines can be formed through various chemical processes, including the reaction between nitrites and secondary amines in certain conditions. It is a N-Nitroso of secondary amine present in Cilazapril. Nitrosamines are part of a broader class of compounds known as N-nitroso compounds. Cilazapril is an angiotensin-converting enzyme (ACE) inhibitor used in the treatment of hypertension and certain cardiovascular conditions. Structurally, it is a prodrug that undergoes hydrolysis in the body to its active form cilazaprilat. As an ACE inhibitor, cilazapril interferes with the renin-angiotensin-aldosterone system, leading to vasodilation and reduced sodium retention. This results in lowered blood pressure and decreased workload on the heart.
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