Nitrosamines can be formed through various chemical processes, including the reaction between nitrites and secondary amines in certain conditions. It is a N-Nitroso of secondary amine present in Dasatinib. Nitrosamines are part of a broader class of compound
Dasatinib is a tyrosine kinase inhibitor used in the treatment of certain types of cancer, notably chronic myeloid leukemia (CML) and Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ ALL). It works by inhibiting the activity of specific tyrosine kinases, including BCR-ABL, which is a fusion protein associated with CML and Ph+ ALL. By blocking these signaling pathways, dasatinib helps to inhibit the proliferation and survival of cancer cells. Dasatinib is typically administered orally and has demonstrated efficacy in patients who are resistant or intolerant to other tyrosine kinase inhibitors. As with any cancer treatment, its use is determined by the patients specific diagnosis and the recommendations of healthcare professionals.
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