Nitrosamines can be formed through various chemical processes, including the reaction between nitrites and secondary amines in certain conditions. It is a N-Nitroso of secondary amine present in Lumefantrine. Nitrosamines are part of a broader class of compounds known as N-nitroso compounds. Lumefantrine is an antimalarial medication commonly used in combination with artemether to treat uncomplicated malaria caused by Plasmodium falciparum. As a member of the arylaminoalcohol group, lumefantrine exhibits its antimalarial properties by interfering with the parasites heme polymerase enzyme, disrupting the formation of hemozoin and leading to the accumulation of toxic heme. This combination therapy is particularly effective against drug-resistant strains of malaria. Lumefantrine is administered orally, and its absorption is enhanced when taken with fatty food.
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