Nitrosamines can be formed through various chemical processes, including the reaction between nitrites and secondary amines in certain conditions. It is a N-Nitroso of secondary amine present in Bedaquiline. Nitrosamines are part of a broader class of compounds known as N-nitroso compounds. Bedaquiline is a medication used in the treatment of drug-resistant tuberculosis (TB). It is classified as an antibiotic and works by inhibiting mycobacterial ATP synthase, disrupting the energy production in Mycobacterium tuberculosis, the bacteria causing TB. Bedaquiline is typically reserved for cases of multidrug-resistant TB (MDR-TB) or extensively drug-resistant TB (XDR-TB) when other treatment options have proven ineffective. The use of bedaquiline is usually part of a comprehensive multidrug regimen for TB.Regular monitoring and adherence to the prescribed treatment plan are crucial for its effectiveness and to minimize the risk of adverse reactions.
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