Nitrosamines can be formed through various chemical processes, including the reaction between nitrites and secondary amines in certain conditions. It is a N-Nitroso of secondary amine present in Neratinib. Nitrosamines are part of a broader class of compounds known as N-nitroso compounds. Neratinib, a tyrosine kinase inhibitor, is utilized in the treatment of HER2-positive breast cancer following surgery, particularly in the early stages, as part of adjuvant therapy. By irreversibly inhibiting signaling pathways associated with HER2, neratinib contributes to the inhibition of cancer cell growth. Typically prescribed orally on a daily basis, it becomes a valuable therapeutic option after prior treatments with anti-HER2 therapies. Neratinib plays a significant role in the comprehensive management of HER2-positive breast cancer, contributing to advancements in treatment strategies for this specific subtype.
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