Nitrosamines can be formed through various chemical processes, including the reaction between nitrites and secondary amines in certain conditions. It is a N-Nitroso of secondary amine present in Dofetilide. Nitrosamines are part of a broader class of compounds known as N-nitroso compounds.
Dofetilide is an antiarrhythmic medication used to treat and maintain normal heart rhythm in individuals with certain types of irregular heartbeats, such as atrial fibrillation or atrial flutter. Structurally, it is a class III antiarrhythmic agent. Dofetilide works by inhibiting specific potassium channels in the heart, prolonging the action potential duration and refractory period, thereby preventing abnormal electrical signals and maintaining a regular heart rhythm. Administered orally, dofetilide requires careful dosing and monitoring due to its potential to cause serious ventricular arrhythmias.
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