Nitrosamines can be formed through various chemical processes, including the reaction between nitrites and secondary amines in certain conditions. It is a N-Nitroso of secondary amine present in Duvelisib. Nitrosamines are part of a broader class of compounds known as N-nitroso compounds. Duvelisib is a dual inhibitor of phosphoinositide 3-kinase (PI3K) and Brutons tyrosine kinase (BTK), making it a valuable therapeutic option in the treatment of certain hematologic malignancies, particularly chronic lymphocytic leukemia (CLL) and follicular lymphoma. By targeting these signaling pathways, duvelisib disrupts the survival and proliferation of cancer cells. This oral medication has demonstrated efficacy in patients who have received at least two prior systemic therapies. Duvelisibs dual inhibition of PI3K and BTK contributes to its ability to modulate the immune response and interfere with the survival signals of cancer cells.
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