Nitrosamines can be formed through various chemical processes, including the reaction between nitrites and secondary amines in certain conditions. It is a N-Nitroso of secondary amine present in Fluorouracil. Nitrosamines are part of a broader class of compounds known as N-nitroso compounds.
Fluorouracil, an anticancer medication, is commonly used in the treatment of various solid tumors, particularly colorectal, breast, and skin cancers. Its application involves interfering with the synthesis of RNA and DNA, inhibiting the growth of cancer cells. Chemically, fluorouracil is a fluorinated pyrimidine analog, disrupting nucleic acid metabolism and ultimately leading to cell death. The drugs mechanism of action makes it a vital component in chemotherapy regimens for its ability to impede cancer cell proliferation.
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