Nitrosamines can be formed through various chemical processes, including the reaction between nitrites and secondary amines in certain conditions. It is a N-Nitroso of secondary amine present in Fostamatinib. Nitrosamines are part of a broader class of compounds known as N-nitroso compounds.
Fostamatinib is an oral medication used in the treatment of certain autoimmune conditions, primarily chronic immune thrombocytopenia (ITP) in adults. ITP is characterized by a low platelet count, leading to an increased risk of bleeding. Fostamatinib is a spleen tyrosine kinase (SYK) inhibitor, working to block signals that contribute to the destruction of platelets. By inhibiting SYK, fostamatinib helps regulate the immune response and increase platelet levels, addressing the underlying cause of ITP.
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