Nitrosamines can be formed through various chemical processes, including the reaction between nitrites and secondary amines in certain conditions. It is a N-Nitroso of secondary amine present in Ibrutinib. Nitrosamines are part of a broader class of compound
Ibrutinib is a targeted cancer therapy belonging to the class of Brutons tyrosine kinase (BTK) inhibitors. Chemically, it is a small molecule that irreversibly inhibits BTK, an enzyme involved in the B-cell receptor signaling pathway. This inhibition interferes with the survival and proliferation of B cells, making ibrutinib particularly effective in the treatment of B-cell malignancies, such as chronic lymphocytic leukemia (CLL), mantle cell lymphoma (MCL), and Waldenströms macroglobulinemia. Ibrutinib has revolutionized the management of these hematological cancers, offering improved outcomes for patients, especially those who may not respond well to traditional chemotherapy. As an oral medication, ibrutinib has demonstrated a favorable safety profile, making it a valuable therapeutic option in the evolving landscape of targeted cancer therapies.
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