Nitrosamines can be formed through various chemical processes, including the reaction between nitrites and secondary amines in certain conditions. It is a N-Nitroso of secondary amine present in Isavuconazonium. Nitrosamines are part of a broader class of compounds known as N-nitroso compounds. Isavuconazonium is the prodrug form of isavuconazole, a triazole antifungal medication. Structurally, isavuconazonium is a water-soluble compound that is converted to isavuconazole in the body. Isavuconazonium is used in the treatment of invasive aspergillosis and mucormycosis in adults. Isavuconazole, the active form, works by inhibiting the synthesis of ergosterol, an essential component of fungal cell membranes. Administered intravenously, isavuconazonium provides a reliable means of delivering isavuconazole to address serious fungal infections. The drug is particularly useful in the treatment of infections caused by Aspergillus species and certain molds belonging to the Mucorales order.
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