Nitrosamines can be formed through various chemical processes, including the reaction between nitrites and secondary amines in certain conditions. It is a N-Nitroso of secondary amine present in Ivacaftor. Nitrosamines are part of a broader class of compounds known as N-nitroso compounds.
Ivacaftor is a medication used to treat certain types of cystic fibrosis (CF) caused by specific genetic mutations. CF is a genetic disorder that primarily affects the lungs and digestive system, leading to the production of thick and sticky mucus that can clog airways and ducts. Ivacaftor is a breakthrough drug known as a "cystic fibrosis transmembrane conductance regulator" (CFTR) modulator, which works by helping the defective CFTR protein function more effectively.
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