Nitrosamines can be formed through various chemical processes, including the reaction between nitrites and secondary amines in certain conditions. It is a N-Nitroso of secondary amine present in Levamlodipine. Nitrosamines are part of a broader class of compounds known as N-nitroso compounds. Levamlodipine is the S-enantiomer of amlodipine, a calcium channel blocker commonly used to treat hypertension and angina. Its chemical structure includes a dihydropyridine ring and an enantiomerically pure S-aminobutyl side chain. As a calcium channel blocker, levamlodipine inhibits the influx of calcium ions into vascular smooth muscle cells, resulting in vasodilation and decreased peripheral vascular resistance. This leads to a reduction in blood pressure and improved blood flow to the heart. Levamlodipine is usually administered orally and has a longer duration of action, allowing for once-daily dosing.
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