Nitrosamines can be formed through various chemical processes, including the reaction between nitrites and secondary amines in certain conditions. It is a N-Nitroso of secondary amine present in Lisinopril. Nitrosamines are part of a broader class of compounds known as N-nitroso compounds.
Lisinopril, an angiotensin-converting enzyme (ACE) inhibitor, is widely used to treat hypertension and heart failure. Its chemistry involves a synthetic peptide structure, a prodrug converted to the active form lisinoprilat after administration. Lisinoprils mechanism inhibits ACE, disrupting the angiotensin II pathway, leading to vasodilation, reduced blood pressure, and improved cardiac function. Administered orally, lisinopril plays a crucial role in cardiovascular management with its lasting impact on peripheral resistance and renal protection.
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