Nitrosamines can be formed through various chemical processes, including the reaction between nitrites and secondary amines in certain conditions. It is a N-Nitroso of secondary amine present in nintedanib. Nitrosamines are part of a broader class of compounds known as N-nitroso compounds. Nintedanib is a tyrosine kinase inhibitor used for the treatment of idiopathic pulmonary fibrosis (IPF), a progressive and debilitating lung disease. Its chemical structure includes a pyridine and indole moiety. Nintedanib exerts its therapeutic effects by inhibiting multiple receptor tyrosine kinases, including those involved in the pathways of platelet-derived growth factor (PDGF), fibroblast growth factor (FGF), and vascular endothelial growth factor (VEGF). By targeting these pathways, nintedanib helps to slow down the progression of fibrosis in the lungs and preserve lung function. It is administered orally and is often part of a comprehensive treatment plan for individuals with IPF.
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