Nitrosamines can be formed through various chemical processes, including the reaction between nitrites and secondary amines in certain conditions. It is a N-Nitroso of secondary amine present in Netupitant. Nitrosamines are part of a broader class of compounds known as N-nitroso compounds.
Netupitant is a neurokinin-1 (NK1) receptor antagonist commonly utilized in combination with palonosetron to prevent nausea and vomiting induced by chemotherapy, especially in regimens with a high or moderate emetogenic risk. By selectively blocking NK1 receptors and inhibiting the action of substance P, a neurotransmitter associated with the vomiting reflex, netupitant provides extended protection against chemotherapy-induced nausea and vomiting.
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