Nitrosamines can be formed through various chemical processes, including the reaction between nitrites and secondary amines in certain conditions. It is a N-Nitroso of secondary amine present in Indacaterol. Nitrosamines are part of a broader class of compounds known as N-nitroso compounds.
Indacaterol is a long-acting beta2-adrenergic agonist (LABA) used as a bronchodilator in the treatment of chronic obstructive pulmonary disease (COPD). Structurally, it is a selective agonist for the beta2-adrenergic receptors. By binding to these receptors in the airways, indacaterol activates the production of cyclic AMP, leading to smooth muscle relaxation and bronchodilation. Administered through inhalation, indacaterol provides sustained relief of bronchoconstriction, improving airflow and respiratory symptoms in patients with COPD.
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