Nitrosamines can be formed through various chemical processes, including the reaction between nitrites and secondary amines in certain conditions. It is a N-Nitroso of secondary amine present in Oritavancin. Nitrosamines are part of a broader class of compounds known as N-nitroso compounds. Oritavancin is a lipoglycopeptide antibiotic used in the treatment of acute bacterial skin and skin structure infections (ABSSSI). Its chemical structure combines a glycopeptide core with lipophilic side chains, enhancing its pharmacokinetic properties and allowing for a prolonged half-life. Oritavancin works by inhibiting bacterial cell wall synthesis, exerting its antibacterial effects primarily against Gram-positive bacteria, including methicillin-resistant Staphylococcus aureus (MRSA). One of the notable features of oritavancin is its extended half-life, which enables a single-dose administration, making it a convenient option for patients.
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