Nitrosamines can be formed through various chemical processes, including the reaction between nitrites and secondary amines in certain conditions. It is a N-Nitroso of secondary amine present in Palbociclib. Nitrosamines are part of a broader class of compounds known as N-nitroso compounds.
Palbociclib is a medication used in the treatment of certain types of breast cancer. It is a cyclin-dependent kinase (CDK) inhibitor, specifically targeting CDK4 and CDK6, which are proteins involved in cell cycle regulation. Chemically, it is a small molecule inhibitor. Palbociclib works by inhibiting these CDKs, leading to cell cycle arrest and preventing the uncontrolled proliferation of cancer cells. It is often used in combination with other therapies, such as hormonal therapies, for the treatment of hormone receptor-positive, HER2-negative advanced or metastatic breast cancer. Palbociclib is typically administered orally in the form of capsules. Its use is determined by healthcare professionals based on the specific characteristics of the cancer and the patients medical history. While it has shown efficacy in certain breast cancer cases, its use may be associated with side effects, and careful monitoring is essential during treatment.
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