Nitrosamines can be formed through various chemical processes, including the reaction between nitrites and secondary amines in certain conditions. It is a N-Nitroso of secondary amine present in Piperaquine. Nitrosamines are part of a broader class of compounds known as N-nitroso compounds.
Piperaquine is an antimalarial medication widely used in combination with artemisinin derivatives, forming artemisinin-based combination therapies (ACTs). These combinations are a key strategy in the treatment and prevention of uncomplicated malaria, recommended by global health organizations. Piperaquine acts by disrupting the life cycle of the malaria parasite within red blood cells. The combination of piperaquine with artemisinin enhances treatment efficacy and helps mitigate the risk of developing resistance to either drug. Regional guidelines may dictate specific formulations and combinations of antimalarials, emphasizing the importance of healthcare professional guidance to ensure proper dosage and adherence to treatment regimens.
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