Nitrosamines can be formed through various chemical processes, including the reaction between nitrites and secondary amines in certain conditions. It is a N-Nitroso of secondary amine present in Pirfenidone. Nitrosamines are part of a broader class of compounds known as N-nitroso compounds.
Pirfenidone is a medication used for the treatment of idiopathic pulmonary fibrosis (IPF), a progressive and irreversible lung disease characterized by the formation of scar tissue in the lungs. Chemically, pirfenidone is a pyridone derivative. The exact mechanism of action of pirfenidone is not fully understood, but it is believed to have anti-inflammatory and anti-fibrotic effects, inhibiting processes associated with the development of fibrosis in the lungs. Pirfenidone is thought to reduce the production of certain growth factors and cytokines involved in fibrosis, ultimately slowing the progression of IPF.
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