Nitrosamines can be formed through various chemical processes, including the reaction between nitrites and secondary amines in certain conditions. It is a N-Nitroso of secondary amine present in Plazomicin. Nitrosamines are part of a broader class of compounds known as N-nitroso compounds.
Plazomicin is an aminoglycoside antibiotic used to treat complicated urinary tract infections (cUTIs) caused by certain resistant bacteria. Its chemical structure is derived from the aminoglycoside class, featuring a complex arrangement of sugars and amino groups. Plazomicin works by binding to the bacterial ribosome, disrupting protein synthesis, and ultimately leading to bacterial cell death. What sets plazomicin apart is its activity against certain strains of bacteria that have developed resistance to other aminoglycosides. It is particularly effective against Enterobacteriaceae, including some strains that produce enzymes responsible for aminoglycoside resistance. Plazomicin is typically administered intravenously and is reserved for situations where other treatment options may be limited due to resistance patterns.
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